Effect of Crocin and Treadmill Exercise on Spermatogenesis and Testis Structure in Streptozotocin-Induced Diabetic Rats: An Experimental Study

Objectives: This study aimed to evaluate the effect of crocin and treadmill exercise on oxidative stress, sperm parameters, testis structure in streptozotocin (STZ)-induced diabetic rats. Materials Methods: In this experimental study, 64 rats induced by a single intraperitoneal (IP) injection STZ (50 mg/ kg) were assigned following groups (n=8/each): healthy control group, group treated daily with at dose 50 mg/kg, one receiving mg/kg for 56 days. Some such as controls diabetics exercised treadmill, well performed crocin. After treatment, all anesthetized, their blood samples taken, serum level insulin, glucose, stress markers measured. Finally, testicles epididymis removed parameters assessed. Results: Treatment along significantly replaced testicular tissue damage, insulin plasma levels (P=0.001). rats, moreover, malondialdehyde (MDA) was increased superoxide dismutase (SOD) catalase (CAT) enzymes activity reduced Crocin administration BW) improved these (P<0.05). Conclusions: Our results confirm antioxidant role positive improving damage caused diabetes.